About the role
Salary: $74,692
Department: Microbiology
Physical work location: 1468 Madison Avenue, New York, New York 10029
Name PI or Supervisor: Maria Gabriela Noval, PhD
Web link to Lab: https://www.novallab.org/
Web link to Department: https://icahn.mssm.edu/about/departments/microbiology
Administrative Contact: Molly Deroy, molly.deroy@mssm.edu
Details of Research Project:
While great effort has been given to understanding the reservoirs of alphavirus persistence, the specific viral and host factors that allow for persistence to occur remain unclear. The postdoctoral fellow will focus on answering the following questions: 1) what are the viral mutations that might drive persistence, 2) when does the shift from non-persistent to persistence infections happen, 3) are viral mutations classified as defective viral genomes or are they attenuated viruses, and 4) what is the viral-host interactome of non-persistent versus persistent viruses?
For that purpose, the postdoctoral fellow will establish complex in vitro models using organoids to recapitulate how viruses persist in tissue-specific sites. The postdoctoral fellow will use replicon reporter systems to evaluate viral mutations over long-term infections in both cell lines and organoids to elucidate site-specific persistent mutations. They will biochemically and virologically characterize mutations that arise during long-term infections to understand how they may contribute to persistence. Additionally, they will perform transcriptomics and RNA-pull down experiments during long-term in vitro infections to characterize the host’s role in generating persistent viruses. Together, these efforts will begin to reveal how persistence may occur through both the lens of the virus and host and may lead to identifying novel targets for therapeutic intervention.
Prior **Technical Duties:**
- Flow-cytometry
- ELISA
- WB
- ELISPOT
- qPCR
- CyTOF data analyses
- Mouse work
**Educational and other Requirements for the position:** MD or PhD
**Experience Required:** MD or PhD
Goals/Outcomes of the Research Project:
Compensation Statement
The Mount Sinai Health System (MSHS) provides salary ranges that comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $74,692.00 - $80,000.00 Annually. Actual salaries depend on a variety of factors, including experience, education, and operational need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.
SPOC-UAW Local 4100 at Icahn School of Medicine (Post Docs), 815 - Microbiology - ISM, Icahn School of Medicine